{"id":705,"date":"2025-02-19T09:02:59","date_gmt":"2025-02-19T09:02:59","guid":{"rendered":"https:\/\/en.hengkangpharm.cn\/?p=705"},"modified":"2025-02-19T09:03:01","modified_gmt":"2025-02-19T09:03:01","slug":"riociguatintermediate_428854-24-4","status":"publish","type":"post","link":"https:\/\/en.hengkangpharm.cn\/index.php\/intermediates\/riociguatintermediate_428854-24-4\/","title":{"rendered":"2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidine-4,5,6-triamine"},"content":{"rendered":"\n<p class=\"has-text-align-center has-ast-global-color-1-background-color has-background\">2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidine-4,5,6-triamine<\/p>\n\n\n\n<div class=\"wp-block-columns alignfull is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"border-style:none;border-width:0px;flex-basis:70%\">\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"235\" height=\"189\" src=\"https:\/\/en.hengkangpharm.cn\/wp-content\/uploads\/2025\/02\/image-33.png\" alt=\"\" class=\"wp-image-717\" style=\"width:357px;height:auto\"\/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><tbody><tr><td class=\"has-text-align-left\" data-align=\"left\">Product Name:2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidine-4,5,6-triamine<\/td><\/tr><tr><td class=\"has-text-align-left\" data-align=\"left\">Chemical Name:2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidine-4,5,6-triamine<\/td><\/tr><tr><td class=\"has-text-align-left\" data-align=\"left\">CAS NO.:428854-24-4<\/td><\/tr><tr><td class=\"has-text-align-left\" data-align=\"left\">Mol. Formula:C<sub>18<\/sub>H<sub>16<\/sub>FN<sub>7<\/sub><\/td><\/tr><tr><td class=\"has-text-align-left\" data-align=\"left\">Mol. Weight:349.37<\/td><\/tr><tr><td class=\"has-text-align-left\" data-align=\"left\">Final API:Riociguat<\/td><\/tr><tr><td class=\"has-text-align-left\" data-align=\"left\">Purity or Assay:\uff1e99%<\/td><\/tr><tr><td class=\"has-text-align-left\" data-align=\"left\"><strong>*All our products under patent are for R&amp;D<\/strong><\/td><\/tr><\/tbody><\/table><\/figure>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-column has-small-font-size is-layout-flow wp-container-core-column-is-layout-fd134cff wp-block-column-is-layout-flow\" style=\"border-style:none;border-width:0px;padding-right:0;padding-left:0;flex-basis:30%\"><ul class=\"wp-block-categories-list alignright wp-block-categories\">\t<li class=\"cat-item cat-item-6\"><a href=\"https:\/\/en.hengkangpharm.cn\/index.php\/category\/apis\/\">APIs<\/a>\n<\/li>\n\t<li class=\"cat-item cat-item-17\"><a href=\"https:\/\/en.hengkangpharm.cn\/index.php\/category\/excipient\/\">Excipient<\/a>\n<\/li>\n\t<li class=\"cat-item cat-item-21\"><a href=\"https:\/\/en.hengkangpharm.cn\/index.php\/category\/fdfs\/\">FDFs<\/a>\n<\/li>\n\t<li class=\"cat-item cat-item-20\"><a href=\"https:\/\/en.hengkangpharm.cn\/index.php\/category\/impurities\/\">Impurities<\/a>\n<\/li>\n\t<li class=\"cat-item cat-item-7\"><a href=\"https:\/\/en.hengkangpharm.cn\/index.php\/category\/intermediates\/\">Intermediates<\/a>\n<\/li>\n\t<li class=\"cat-item cat-item-13\"><a href=\"https:\/\/en.hengkangpharm.cn\/index.php\/category\/mrna-materials\/\">mRNA materials<\/a>\n<\/li>\n\t<li class=\"cat-item cat-item-18\"><a href=\"https:\/\/en.hengkangpharm.cn\/index.php\/category\/news\/\">News<\/a>\n<ul class='children'>\n\t<li class=\"cat-item cat-item-19\"><a href=\"https:\/\/en.hengkangpharm.cn\/index.php\/category\/news\/hengkang-news\/\">Hengkang News<\/a>\n<\/li>\n<\/ul>\n<\/li>\n\t<li class=\"cat-item cat-item-14\"><a href=\"https:\/\/en.hengkangpharm.cn\/index.php\/category\/nucleoside\/\">Nucleoside<\/a>\n<ul class='children'>\n\t<li class=\"cat-item cat-item-15\"><a href=\"https:\/\/en.hengkangpharm.cn\/index.php\/category\/nucleoside\/modified-nucleoside\/\">Modified Nucleoside<\/a>\n<\/li>\n\t<li class=\"cat-item cat-item-16\"><a href=\"https:\/\/en.hengkangpharm.cn\/index.php\/category\/nucleoside\/protected-nucleoside\/\">Protected Nucleoside<\/a>\n<\/li>\n<\/ul>\n<\/li>\n\t<li class=\"cat-item cat-item-8\"><a href=\"https:\/\/en.hengkangpharm.cn\/index.php\/category\/phosphoramidites\/\">Phosphoramidites<\/a>\n<ul class='children'>\n\t<li class=\"cat-item cat-item-12\"><a href=\"https:\/\/en.hengkangpharm.cn\/index.php\/category\/phosphoramidites\/2-fluoro-phosphoramidites\/\">2&#039;-Fluoro Phosphoramidites<\/a>\n<\/li>\n\t<li class=\"cat-item cat-item-11\"><a href=\"https:\/\/en.hengkangpharm.cn\/index.php\/category\/phosphoramidites\/2-o-me-phosphoramidites\/\">2&#039;-O-Me Phosphoramidites<\/a>\n<\/li>\n\t<li class=\"cat-item cat-item-9\"><a href=\"https:\/\/en.hengkangpharm.cn\/index.php\/category\/phosphoramidites\/dna-phosphoramidites\/\">DNA Phosphoramidites<\/a>\n<\/li>\n\t<li class=\"cat-item cat-item-10\"><a href=\"https:\/\/en.hengkangpharm.cn\/index.php\/category\/phosphoramidites\/tbdms-phosphoramidites\/\">TBDMS Phosphoramidites<\/a>\n<\/li>\n<\/ul>\n<\/li>\n\t<li class=\"cat-item cat-item-1\"><a href=\"https:\/\/en.hengkangpharm.cn\/index.php\/category\/uncategorized\/\">Uncategorized<\/a>\n<\/li>\n<\/ul><\/div>\n<\/div>\n\n\n\n<p class=\"has-text-align-left\">Synonym: 2-[1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidine-4,5,6-triamine;2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidine-4,5,6-triamine;Riociguat intermediate<\/p>\n\n\n\n<p><\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidine-4,5,6-triamine Product Name:2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidine-4,5,6-triamine Chemical Name:2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidine-4,5,6-triamine CAS NO.:428854-24-4 Mol. Formula:C18H16FN7 Mol. Weight:349.37 Final API:Riociguat Purity or Assay:\uff1e99% *All our products under patent are for R&amp;D Synonym: 2-[1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidine-4,5,6-triamine;2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidine-4,5,6-triamine;Riociguat intermediate<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_uag_custom_page_level_css":"","site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[7],"tags":[],"class_list":["post-705","post","type-post","status-publish","format-standard","hentry","category-intermediates"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.7 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidine-4,5,6-triamine - Zhejiang Hengkang Pharmaceutical<\/title>\n<meta name=\"description\" content=\"As a synthetic intermediate of Riociguat, 2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidine-4,5,6-triamine undergoes a series of chemical reactions to ultimately convert into molecules of Riociguatwith pharmacological activity. 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