{"version":"1.0","provider_name":"Zhejiang Hengkang Pharmaceutical","provider_url":"https:\/\/en.hengkangpharm.cn","author_name":"HengkangPharm","author_url":"https:\/\/en.hengkangpharm.cn\/index.php\/author\/admin\/","title":"2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidine-4,5,6-triamine - Zhejiang Hengkang Pharmaceutical","type":"rich","width":600,"height":338,"html":"<blockquote class=\"wp-embedded-content\" data-secret=\"uyM33bjoHe\"><a href=\"https:\/\/en.hengkangpharm.cn\/index.php\/intermediates\/riociguatintermediate_428854-24-4\/\">2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidine-4,5,6-triamine<\/a><\/blockquote><iframe sandbox=\"allow-scripts\" security=\"restricted\" src=\"https:\/\/en.hengkangpharm.cn\/index.php\/intermediates\/riociguatintermediate_428854-24-4\/embed\/#?secret=uyM33bjoHe\" width=\"600\" height=\"338\" title=\"&#8220;2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidine-4,5,6-triamine&#8221; &#8212; Zhejiang Hengkang Pharmaceutical\" data-secret=\"uyM33bjoHe\" frameborder=\"0\" marginwidth=\"0\" marginheight=\"0\" scrolling=\"no\" class=\"wp-embedded-content\"><\/iframe><script>\n\/*! This file is auto-generated *\/\n!function(d,l){\"use strict\";l.querySelector&&d.addEventListener&&\"undefined\"!=typeof URL&&(d.wp=d.wp||{},d.wp.receiveEmbedMessage||(d.wp.receiveEmbedMessage=function(e){var t=e.data;if((t||t.secret||t.message||t.value)&&!\/[^a-zA-Z0-9]\/.test(t.secret)){for(var s,r,n,a=l.querySelectorAll('iframe[data-secret=\"'+t.secret+'\"]'),o=l.querySelectorAll('blockquote[data-secret=\"'+t.secret+'\"]'),c=new RegExp(\"^https?:$\",\"i\"),i=0;i<o.length;i++)o[i].style.display=\"none\";for(i=0;i<a.length;i++)s=a[i],e.source===s.contentWindow&&(s.removeAttribute(\"style\"),\"height\"===t.message?(1e3<(r=parseInt(t.value,10))?r=1e3:~~r<200&&(r=200),s.height=r):\"link\"===t.message&&(r=new URL(s.getAttribute(\"src\")),n=new URL(t.value),c.test(n.protocol))&&n.host===r.host&&l.activeElement===s&&(d.top.location.href=t.value))}},d.addEventListener(\"message\",d.wp.receiveEmbedMessage,!1),l.addEventListener(\"DOMContentLoaded\",function(){for(var e,t,s=l.querySelectorAll(\"iframe.wp-embedded-content\"),r=0;r<s.length;r++)(t=(e=s[r]).getAttribute(\"data-secret\"))||(t=Math.random().toString(36).substring(2,12),e.src+=\"#?secret=\"+t,e.setAttribute(\"data-secret\",t)),e.contentWindow.postMessage({message:\"ready\",secret:t},\"*\")},!1)))}(window,document);\n\/\/# sourceURL=https:\/\/en.hengkangpharm.cn\/wp-includes\/js\/wp-embed.min.js\n<\/script>\n","description":"As a synthetic intermediate of Riociguat, 2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidine-4,5,6-triamine undergoes a series of chemical reactions to ultimately convert into molecules of Riociguatwith pharmacological activity. Riociguat stimulates the activity of soluble guanylate cyclase, increases the concentration of intracellular cyclic guanosine monophosphate, thereby relaxing vascular smooth muscle, dilating pulmonary artery blood vessels, reducing pulmonary artery pressure, and improving patient symptoms and prognosis.","thumbnail_url":"https:\/\/en.hengkangpharm.cn\/wp-content\/uploads\/2025\/02\/image-33.png","thumbnail_width":235,"thumbnail_height":189}