1.0Zhejiang Hengkang Pharmaceuticalhttps://en.hengkangpharm.cnHengkangPharmhttps://en.hengkangpharm.cn/index.php/author/admin/rich600338<blockquote class="wp-embedded-content" data-secret="orZ8lD2AMi"><a href="https://en.hengkangpharm.cn/index.php/intermediates/roxadustatintermediate_2222121-33-5/">Ethyl 5-(2-bromo-4-phenoxyphenyl)oxazole-4-carboxylate</a></blockquote><iframe sandbox="allow-scripts" security="restricted" src="https://en.hengkangpharm.cn/index.php/intermediates/roxadustatintermediate_2222121-33-5/embed/#?secret=orZ8lD2AMi" width="600" height="338" title="“Ethyl 5-(2-bromo-4-phenoxyphenyl)oxazole-4-carboxylate” — Zhejiang Hengkang Pharmaceutical" data-secret="orZ8lD2AMi" frameborder="0" marginwidth="0" marginheight="0" scrolling="no" class="wp-embedded-content"></iframe><script> /*! This file is auto-generated */ !function(d,l){"use strict";l.querySelector&&d.addEventListener&&"undefined"!=typeof URL&&(d.wp=d.wp||{},d.wp.receiveEmbedMessage||(d.wp.receiveEmbedMessage=function(e){var t=e.data;if((t||t.secret||t.message||t.value)&&!/[^a-zA-Z0-9]/.test(t.secret)){for(var s,r,n,a=l.querySelectorAll('iframe[data-secret="'+t.secret+'"]'),o=l.querySelectorAll('blockquote[data-secret="'+t.secret+'"]'),c=new RegExp("^https?:$","i"),i=0;i<o.length;i++)o[i].style.display="none";for(i=0;i<a.length;i++)s=a[i],e.source===s.contentWindow&&(s.removeAttribute("style"),"height"===t.message?(1e3<(r=parseInt(t.value,10))?r=1e3:~~r<200&&(r=200),s.height=r):"link"===t.message&&(r=new URL(s.getAttribute("src")),n=new URL(t.value),c.test(n.protocol))&&n.host===r.host&&l.activeElement===s&&(d.top.location.href=t.value))}},d.addEventListener("message",d.wp.receiveEmbedMessage,!1),l.addEventListener("DOMContentLoaded",function(){for(var e,t,s=l.querySelectorAll("iframe.wp-embedded-content"),r=0;r<s.length;r++)(t=(e=s[r]).getAttribute("data-secret"))||(t=Math.random().toString(36).substring(2,12),e.src+="#?secret="+t,e.setAttribute("data-secret",t)),e.contentWindow.postMessage({message:"ready",secret:t},"*")},!1)))}(window,document); //# sourceURL=https://en.hengkangpharm.cn/wp-includes/js/wp-embed.min.js </script> Ethyl 5-(2-bromo-4-phenoxyphenyl)oxazole-4-carboxylate is one of the intermediates of Roxadustat and can be used for the synthesis of Roxadustat. Roxadustat is a novel hypoxia inducible factor (HIF) - prolyl hydroxylase (PH) enzyme inhibitor that stabilizes HIF, inhibits its degradation, activates transcription of related genes, generates corresponding physiological responses, moderately increases the concentration of erythropoietin, enhances the sensitivity of erythropoietin (EPO) receptors, coordinates red blood cell production, reduces ferritin levels, increases transferrin receptor content and activity, promotes iron absorption and utilization, and has good tolerance.https://en.hengkangpharm.cn/wp-content/uploads/2025/02/image-52.png179124