1.0Zhejiang Hengkang Pharmaceuticalhttps://en.hengkangpharm.cnHengkangPharmhttps://en.hengkangpharm.cn/index.php/author/admin/2-[1-[(2-fluorophenyl)methyl]pyrazolo[3,4-b]pyridin-3-yl]-5-[(E)-phenylazo]pyrimidine-4,6-diamine - Zhejiang Hengkang Pharmaceuticalrich600338<blockquote class="wp-embedded-content" data-secret="6k2J0X3KId"><a href="https://en.hengkangpharm.cn/index.php/intermediates/riociguatintermediate_370879-49-5/">2-[1-[(2-fluorophenyl)methyl]pyrazolo[3,4-b]pyridin-3-yl]-5-[(E)-phenylazo]pyrimidine-4,6-diamine</a></blockquote><iframe sandbox="allow-scripts" security="restricted" src="https://en.hengkangpharm.cn/index.php/intermediates/riociguatintermediate_370879-49-5/embed/#?secret=6k2J0X3KId" width="600" height="338" title="“2-[1-[(2-fluorophenyl)methyl]pyrazolo[3,4-b]pyridin-3-yl]-5-[(E)-phenylazo]pyrimidine-4,6-diamine” — Zhejiang Hengkang Pharmaceutical" data-secret="6k2J0X3KId" frameborder="0" marginwidth="0" marginheight="0" scrolling="no" class="wp-embedded-content"></iframe><script>
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2-[1-[(2-fluorophenyl)methyl]pyrazolo[3,4-b]pyridin-3-yl]-5-[(E)-phenylazo]pyrimidine-4,6-diamine is one of the intermediates in the synthesis of Riociguat, an important signaling enzyme that can be activated by nitric oxide (NO) to catalyze the conversion of guanosine triphosphate (GTP) to the second messenger cyclic guanosine monophosphate (cGMP).https://en.hengkangpharm.cn/wp-content/uploads/2025/02/image-32.png235131