1.0Zhejiang Hengkang Pharmaceuticalhttps://en.hengkangpharm.cnHengkangPharmhttps://en.hengkangpharm.cn/index.php/author/admin/rich600338<blockquote class="wp-embedded-content" data-secret="wUCdrD8Tm6"><a href="https://en.hengkangpharm.cn/index.php/intermediates/macitentanintermediate_1433875-21-8/">5-(4-Bromophenyl)-6-(2-((5-bromo-2-pyrimidinyl)oxy)ethoxy)-4-pyrimidinamine</a></blockquote><iframe sandbox="allow-scripts" security="restricted" src="https://en.hengkangpharm.cn/index.php/intermediates/macitentanintermediate_1433875-21-8/embed/#?secret=wUCdrD8Tm6" width="600" height="338" title="“5-(4-Bromophenyl)-6-(2-((5-bromo-2-pyrimidinyl)oxy)ethoxy)-4-pyrimidinamine” — Zhejiang Hengkang Pharmaceutical" data-secret="wUCdrD8Tm6" frameborder="0" marginwidth="0" marginheight="0" scrolling="no" class="wp-embedded-content"></iframe><script> /*! This file is auto-generated */ !function(d,l){"use strict";l.querySelector&&d.addEventListener&&"undefined"!=typeof URL&&(d.wp=d.wp||{},d.wp.receiveEmbedMessage||(d.wp.receiveEmbedMessage=function(e){var t=e.data;if((t||t.secret||t.message||t.value)&&!/[^a-zA-Z0-9]/.test(t.secret)){for(var s,r,n,a=l.querySelectorAll('iframe[data-secret="'+t.secret+'"]'),o=l.querySelectorAll('blockquote[data-secret="'+t.secret+'"]'),c=new RegExp("^https?:$","i"),i=0;i<o.length;i++)o[i].style.display="none";for(i=0;i<a.length;i++)s=a[i],e.source===s.contentWindow&&(s.removeAttribute("style"),"height"===t.message?(1e3<(r=parseInt(t.value,10))?r=1e3:~~r<200&&(r=200),s.height=r):"link"===t.message&&(r=new URL(s.getAttribute("src")),n=new URL(t.value),c.test(n.protocol))&&n.host===r.host&&l.activeElement===s&&(d.top.location.href=t.value))}},d.addEventListener("message",d.wp.receiveEmbedMessage,!1),l.addEventListener("DOMContentLoaded",function(){for(var e,t,s=l.querySelectorAll("iframe.wp-embedded-content"),r=0;r<s.length;r++)(t=(e=s[r]).getAttribute("data-secret"))||(t=Math.random().toString(36).substring(2,12),e.src+="#?secret="+t,e.setAttribute("data-secret",t)),e.contentWindow.postMessage({message:"ready",secret:t},"*")},!1)))}(window,document); //# sourceURL=https://en.hengkangpharm.cn/wp-includes/js/wp-embed.min.js </script> 5-(4-Bromophenyl)-6-(2-((5-bromo-2-pyrimidinyl)oxy)ethoxy)-4-pyrimidinamine is mainly used as a pharmaceutical intermediate and is one of the intermediates for synthesizing Macitentan. Macitentan is an orally active endothelin ETA and ETB receptor antagonist that can block endothelin induced vasoconstriction in the trachea and large arteries.https://en.hengkangpharm.cn/wp-content/uploads/2025/02/image-78.png255141